Circulating and Tissue Forms of the Intestinal Growth Factor, Glucagon-Like Peptide-2*
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چکیده
منابع مشابه
Circulating and tissue forms of the intestinal growth factor, glucagon-like peptide-2.
Glucagon-like peptide-2 (GLP-2) has recently been identified as a stimulator of intestinal epithelial growth, prompting the development of RIA and HPLC methodologies to study this peptide in more detail. A GLP-2-specific antiserum (UTTH-7) was developed that recognizes amino acids 25-30 of human and rat GLP-2-(1-33). UTTH-7 cross-reacts with N- and C-terminally modified forms of GLP-2, progluca...
متن کاملGlucagon-like peptide 2: a nutrient-responsive gut growth factor.
Glucagon-like peptide 2 (GLP-2) is a 33-amino acid peptide derived from the tissue-specific, post-translational processing of the proglucagon gene expressed in the intestinal enteroendocrine L-cell. The primary stimulus for GLP-2 secretion is nutrient intake, and involves direct luminal stimulation of the L-cell as well as indirect enteroendocrine and neural mechanisms. The biological activity ...
متن کاملDiabetic intestinal growth adaptation and glucagon-like peptide 2 in the rat: effects of dietary fibre.
BACKGROUND/AIMS Dietary fibre influence growth and function of the upper gastrointestinal tract. This study investigates the importance of dietary fibre in intestinal growth in experimental diabetes, and correlates intestinal growth with plasma levels of the intestinotrophic factor, glucagon-like peptide 2 (GLP-2). METHODS Male Wistar rats were randomised to the following groups: two streptoz...
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Injury, inflammation, or resection of the small intestine results in severe compromise of intestinal function. Nevertheless, therapeutic strategies for enhancing growth and repair of the intestinal mucosal epithelium are currently not available. We demonstrate that nude mice bearing subcutaneous proglucagon-producing tumors exhibit marked proliferation of the small intestinal epithelium. The fa...
متن کاملGlucagon-like Peptide-2.
Multiple peptide hormones produced within the gastrointestinal system aid in the regulation of energy homeostasis and metabolism. Among these is the intestinotrophic peptide glucagon-like peptide-2 (GLP-2), which is released following food intake and plays a significant role in the adaptive regulation of bowel mass and mucosal integrity. The discovery of GLP-2's potent growth-promoting and cyto...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 1997
ISSN: 0013-7227,1945-7170
DOI: 10.1210/endo.138.11.5482